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Includes WPA Administrator E. J. Griffith, State Senator Dick Groener and 1956 Rose Festival queen Sharon Frey Grundfossen; for the name Hall, 1975 accession is missing all photos where first initial is B through I.
Includes Judge Herbert M. Schwab, Portland City Commissioner Mildred Schwab, quadriplegic activist Laurie Schwartz, and the Seagraves family (Anna Eleanor ("Sisite") Dall Seagraves - granddaughter of FDR, Van Seagraves and Nicholas Delano Seagraves).
Includes 1948 Miss Oregon Joyce Davis Stevens, photos of Sen. Adlai Stevenson in Oregon, Oregon Journal manager Fred Stickel, police chief Ron Still, Oregon Journal associate editor Tom Stimmel, Oregon State football coach Alonzo L. ("Lon") Stiner, dancer and 1961 Junior Rose queen Julane Eva Stites, and Congressman Lowell Stockman; Most pre-1960 photos for Stevens, K-Z are missing from the colleciton.
June 1, 2008 at 01:14 AM · With chudman and filimstar it was always the same post; have I got a bow for you, or person x is an insult to the universe. THe one I miss is Linda Blair, or whatever her name was.
June 1, 2008 at 04:08 AM · Oh, I thought you meant someone else. I have this memory of a very fiery member but I'll say no more. She might come back. I do miss Emil and Gennady and various other old salts, even though Emil tried to sock me a few times too many. Too much ducking and weaving and counter-parrying.
June 1, 2008 at 06:30 AM · I second Mara 100%. I especially miss Emil and Sung Duk among others. Also haven't seen postings from Igor Yuzefovich and Raphael Klayman for some time. With those guys around, together with all the great ones still sticking around as Mara mentioned, discussions were definitely held at a different level. What a pitty.
Although it is difficult with many imaging modalities, including MRI, computed tomography, positron emission tomography, and ultrasound, to interrogate more than one parameter simultaneously, optical imaging lends itself to such multiplexing of even molecular information secondary to the ease of separating wavelengths of light. Thus, as was demonstrated recently (67), it is possible to use near-infrared fluorescent smart probes to image multiple gene expressions simultaneously and independently. A second channel allows greater quantitation of concentration based on signal intensity acquired during surface imaging. More importantly, miniarrays of several injected probes for in vivo target assessment may be implemented. For example, a breast lesion may be better characterized with a combination of enzyme activities such as MMP-2 combined with tyrosine kinase evaluation rather than either one alone. It is likely that each group of cancers will have a several targets that would help define the imaging miniarray most suited for characterization of that disease. These multichannel techniques are applicable for both subsurface imaging and imaging of deeper tissue.
Near-infrared fluorescence imaging. A micrometastasis-sized tumor brightly fluoresces (right) after i.v. administration of a cathepsin B selective protease probe. White light image (left) for anatomical correlation. Please see text for details (from Ref. 30, reprinted with permission).
Real-time imaging of protease inhibition. Control mouse (left) and treated mouse (right), both with two HT-1080 tumors overexpressing MMP-2. Tumors from the mouse pretreated with an MMP-2 inhibitor show markedly decreased fluorescence compared with untreated tumors (from Ref. 32, reprinted with permission).
NIRF cathepsin B imaging of intestinal adenomas. White light image (left) of excised bowel from an APC min mouse reveals many fewer small adenomas than fluorescent imaging (right) after administration of cathepsin B probe (from Ref. 60, reprinted with permission).
Aggressiveness of breast cancer revealed with cathepsin B imaging. An aggressive (left) and well-differentiated (right) breast tumor implanted in a nude mouse have different fluorescent signal intensities correlating with their invasive and metastatic potential (from Ref. 25, reprinted with permission). 2b1af7f3a8